Osteoarthritis (OA), a degenerative joint disease, is the most common joint disease in the world.
Osteoarthritis (OA), a degenerative joint disease, is the most common joint disease in the world. Approximately 40% of men and 47% of women develop OA and in 2017 it affected over 300 million people. The knee is the most commonly affected joint, followed by the hand, and then the hip.
Treatment options include oral medications, topical medications, joint injections, supplements, physical therapy, bracing and therapy. The purpose of this review is to discuss the role of oral corticosteroids in the treatment of OA. Case You are evaluating your treatment options for a healthy 45 year old male with a history of left knee ACL repair in the remote past and mild OA by history and exam today.
The patient is inquiring about oral corticosteroids as a treatment option. Which of the following is not a feared adverse effect of glucocorticoids on the musculoskeletal system? A) Osteopenia and Osteoporosis B) Avascular Necrosis C) Myopathy D) Muscle Hypertrophy Inflammation is implicated in the pathogenesis of OA.
It is driven by irritation of chondrocytes and can be primary or secondary. The excessive stress leads to increased levels of interleukin 1β (IL-1β) and tumor necrosis factor (TNF)-α expression. Synovitis is considered a key component of OA in all stages of the disease.
Persistent synovial inflammation leads to hyperplasia and hypertrophy and eventually osseous changes. This sets the theoretical basis for the use of corticosteroids in the treatment of OA. Note that OA is considered a localized pathological state and not a systemic illness.
If you are experiencing symptoms that may be related to oral corticosteroids for osteoarthritis, it is important to see a sports medicine physician. Early evaluation and treatment typically lead to better outcomes. Do not ignore pain or symptoms that are limiting your activity.
*This article is for educational purposes only and does not substitute for professional medical advice. Always consult a qualified healthcare provider.*
Connect with a doctor, physical therapist, or imaging center near you.
Find a Provider Near You →